From the Latin for 'to find' or 'to discover' , Pastel's InVenio technology is a proteomics and protein biomarker discovery and validation platform that uses specialised capture molecules in combination with sophisticated microfluidics, surface chemistry, detection and bioinformatics techniques to identify and quantify many 100's of thousands and even millions of different proteins in a simple to use 'plug and play' format similar to that employed by current next generation DNA sequencers.

Key capabilities

Pastel has a vision that is to do for proteomics and protein biomarkers what the next generation DNA sequencers have achieved for the genomics field. Pastel is developing InVenio™ technology which will have the following capabilities:
simple, easy to use instrumentation and bioinformatics
able to rapidly detect, identify and quantify all human proteins
rapidly detect & quantify virtually all proteins from any organism
discover previously unknown proteins
detect common post-translational modifications
with the ultimate in high sensitivity detection (single molecule)
able to piggyback on current detection platforms (laser/fluorescence, chip/FET)

Initial bioinformatics show that InVenio technology will be able to:

uniquely identify 99% of those human proteins in the Uniprot database (34,661 of the 35,018 present)
uniquely identify 89% of all proteins deriving from viral or bacterial human pathogens (1,007 viral strains and 123 bacterial strains) and correctly classifying 99.7% of these strains
identify protein sequences from viral or bacterial strains not normally pathogenic for humans (100% of 650 non-human viral strains could be detected by the presence of at least one uniquely detectable protein) : simulating SARS-like epidemics or biowarfare threats,
uniquely identify the vast majority of proteins from all other organisms (e.g. viral, bacterial, fungal, protozoan, nematode worm, drosophila through to zebra fish, mice, rats and higher primates but also including plants)

Development phase

Pastel's scientists have taken the InVenio™ technology from an idea on a piece of paper and developed the bioinformatics, capture molecules, screening procedures and detection systems that enable us to detect, identify and quantify target molecules at single molecule sensitivity.

We are currently looking at the techniques required to move the InVenio™ technology from a research tool to a fully operational, simple and rapid, instrument platform that will serve as the foundations for the next phase of proteomics and protein biomarker discovery work.

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